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Periodical article Periodical article Leiden University catalogue Leiden University catalogue WorldCat catalogue WorldCat
Title:Modelling the relationship between antiretroviral treatment and HIV prevention: limitations of the Spectrum AIDS Impact Model in a changing policy environment
Author:Nattrass, NicoliISNI
Year:2007
Periodical:African Journal of AIDS Research
Volume:6
Issue:2
Pages:129-137
Language:English
Geographic term:South Africa
Subjects:AIDS
health policy
medicinal drugs
External link:https://www.tandfonline.com/doi/pdf/10.2989/16085900709490407
Abstract:This paper shows how two publicly available epidemiological modelling packages, namely the Spectrum AIDS Impact Model - internationally the most influential AIDS impact model - and the demographic model produced by the Actuarial Society of South Africa, the ASSA2003 AIDS and Demographic Model, predict very different impacts from rolling out highly active antiretroviral treatment (HAART) on new HIV infections. Using South Africa as a case study, the paper shows that the ASSA2003 model predicts a significant drop in new HIV infections as HAART is rolled out, whereas the Spectrum model assumes that HAART does not have a preventative impact (and in fact generates a small increase in new HIV infections). Users will thus draw different conclusions about the public health benefits of HAART depending on which modelling package they use. Despite being presented as a policy-oriented modelling tool capable of exploring 'what if' questions about the impact of different policy choices, the Spectrum model is ill-equipped to do so with regard to a HAART rollout. Unlike Spectrum, ASSA2003 is more flexible and its assumptions are clear. Better modelling and more information (including about the relationship between HAART and sexual risk behaviour) is required to develop appropriate public-policy modelling for the HAART era. Bibliogr., notes, ref., sum. [Journal abstract]
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